Impact of NVP

NVP can have a physical, psychological and social impact.

Physiological impact

  • Poor nutrition or malnutrition, dehydration or electrolyte imbalance, poor sleep1-3
  • The severity of nausea is comparable to that induced by chemotherapy4

Psychological impact

  • Detrimental far-reaching consequences on quality of life5-8
  • NVP interferes in everyday activities for 40% of women5-9 leading to feelings of isolation, helplessness and depression10-12

Social impact

  • On average, up to 40% of women need time off work due to NVP8,13-16
  • Partners lose an average of 3.5 days from work in order to care for partners with NVP14

Further Impact:

  • NVP is the most common indication for admission to hospital during the first trimester of pregnancy1,2,17 with 65% being emergency admissions18
  • Severe NVP can be associated with severe dehydration, malnutrition and electrolyte imbalances1,2,3


  1. Royal College of Obstetricians and Gynaecologists. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum (Green-top Guideline No. 69). 22 June 2016. Royal College of Obstetricians and Gynaecologists: London.
  2. Mitchell-Jones N, et al. Ambulatory versus inpatient management of severe nausea and vomiting of pregnancy: a randomised control trial with patient preference arm. BMJ Open 2017;7:e017566. doi:10.1136/bmjopen-2017-017566.
  3. Stokke G, Gjelsvik BL, Flaatten KT, Birkeland E, Flaatten H, Trovik J. Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10-year retrospective cohort study. Acta Obstet Gynecol Scand. 2015;94:359–67.
  4. Lacroix R, Eason E, Melzack R. Nausea and vomiting during pregnancy: a prospective study of its frequency, intensity, and patterns of change. Am J Obstet Gynecol 2000; 182(4): 931-937.
  5. Association of Professors of Gynecology and Obstetrics. Nausea and Vomiting of Pregnancy. Continuing series on Women’s Health Education. 2011; Jespersen & Associates, LLC, Boston, Massachusetts.
  6. Mazzotta P. Psychosocial Morbidity Among Women with Nausea and Vomiting of Pregnancy: Prevalence: Prevalence and Association with Anti-Emetic Therapy. J. Psychosom Obstet Gynecol 2000;21: 129-136.
  7. O’Brien B et al. Nausea and vomiting during pregnancy: effects on the quality of women’s lives. Birth 1992; 19:138-143.
  8. Vellacott ID et al. Nausea and vomiting in early pregnancy. Int J Gynecol Obstet. 1988;27:57-62.
  9. Mazzotta P. Attitudes, Management and Consequences of Nausea and Vomiting of Pregnancy in the United States and Canada.Internat J Gynecol Obstet 2000; 70: 359-365.
  10. Simpson SW, Goodwin TM, Robins S, et al. Psychological factors and hyperemesis gravidarum. J Women’s Health. 2001;10(5):471–477.
  11. Tan, P (2010). Anxiety and depression in hyperemesis gravidarum: Prevalence, risk factors and correlation with clinical severity. European Journal of Obstetrics & Gynecology and Reproductive Biology, 149, 153-158.
  12. Kramer, J. et al. Nausea and Vomiting of Pregnancy: Prevalence, Severity and Relation to Psychosocial Health. The American Journal of Maternal/Child Nursing. 2013; 38(1): 21-27.
  13. Gadsby R et al. A prospective study of nausea and vomiting during pregnancy. Brit J Gen Pract. 1993:43:245–8.
  14. Piwko C, Koren G, Babashov V, Vicente C, Einarson TR. Economic burden of nausea and vomiting of pregnancy in the USA. J Popul Ther Clin Pharmacol. 2013;20(2):e149-e160.
  15. Dorheim, SK. et al. Sick leave during pregnancy: a longitudinal study of rates and risk factors in a Norwegian population. BJOG. 2013; 210: 521-530.
  16. Tan, A. et al. Nausea and vomiting of pregnancy: Effects on quality of life and day-to-day function. Aust N Z J Obstet Gynaecol. 2017; 1-1.
  17. Gazmararian JA, Petersen R, Jamieson DJ, et al. Hospitalizations During Pregnancy Among Managed Care Enrollees. Obstet Gynecol 2002;100:94 –100.
  18. NHS Digital. HES data 2016/17. Available at: Accessed July 2018.