Xonvea (doxylamine and pyridoxine) for Nausea and Vomiting of Pregnancy

product box with pill

Xonvea

Xonvea is indicated for the treatment of Nausea and Vomiting of Pregnancy (NVP) in women where conservative management has failed. It is the only licensed medicine in the UK for the management of NVP.1

Xonvea is a fixed-dose combination of:

  • 10 mg doxylamine succinate (histamine H1 receptor antagonist)
  • 10 mg pyridoxine hydrochloride (vitamin B6 pro-drug)

This fixed-dose combination is delivered in lactose-free, gastro-resistant delayed-release tablets specifically for the treatment of NVP.

The combination of actives in Xonvea has over 40 years of prescribed use in the US and Canada2-4

  • The combination of actives in Xonvea is recommended in the USA as first line pharmacotherapy for the treatment of NVP and has been licensed in the USA since 20133
  • The combination of actives in Xonvea is recommended in Canada as first line pharmacotherapy for the treatment of NVP and has been licensed in Canada since 19794

With the availability of Xonvea in the UK, healthcare professionals can now prescribe a licensed medicine for the treatment of NVP in women where conservative management has failed.

For more information, please visit the safety page or click here

map of the USA and Canada.

Xonvea employs a delayed-release action which means taking it at night time will lead to a peak in blood levels in the morning, when pregnant women may need it most1.

References:

  1. Xonvea 10 mg/10 mg gastro-resistant tablets Summary of Product Characteristics.
  2. Madjunkova S, Maltepe C, Koren G. The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin®) for the treatment of nausea and vomiting of pregnancy. Pediatr Drugs 2014; 16: 199-211.
  3. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 189, January 2018. Nausea and vomiting of pregnancy. Obstet. Gynecol. 2018;131:e15-e30.
  4. The Society of Obstetricians and Gynaecologists of Canada. The Management of Nausea and Vomiting of Pregnancy SOGC Clinical Practice Guideline No.339, December 2016. J Obstet Gynaecol Can. 2016;38(12):1127-1137.