Xonvea (doxylamine and pyridoxine) for Nausea and Vomiting of Pregnancy

Before starting your medicine, please read the patient information leaflet that is included in your Xonvea pack.

Doxylamine and pyridoxine can be used to manage the symptoms of Nausea and Vomiting of Pregnancy in women for whom conservative management, like diet and lifestyle changes, has not been successful.

Why have I been prescribed Xonvea?

Xonvea is used by pregnant women, to help stop them from feeling sick (nausea) and being sick (vomiting). It is given when changes in diet or other non-medicinal treatments have not worked, such as ginger, acupressure and rest.

Nausea and Vomiting of Pregnancy (NVP), commonly known as morning sickness, is the most common medical condition of pregnancy, affecting up to 80% of all pregnant women.

Typically symptoms start between 4-7 weeks of pregnancy and can occur at any time of the day or night. Up to 20% of women continue to experience nausea, vomiting and retching beyond 20 weeks of pregnancy.

You have been prescribed Xonvea because you have been diagnosed with NVP and changes in diet and other non-medicinal treatments have failed. This can be very unpleasant and may be affecting your day-to-day life.

What is Xonvea (doxylamine and pyridoxine)?

Xonvea is a tablet formulated to reduce the symptoms of Nausea and Vomiting of Pregnancy. Xonvea contains two medicines called: ‘doxylamine succinate 10mg’ and ‘pyridoxine hydrochloride 10mg’.

  • Doxylamine succinate belongs to a group of medicines called ‘antihistamines’
  • Pyridoxine hydrochloride is another name for Vitamin B6

How should I take my Xonvea tablets?

Always take this medicine exactly as your doctor, pharmacist or nurse has told you. Check with your doctor, pharmacist or nurse if you are not sure. Continued need for Xonvea should be reassessed as the pregnancy progresses.

How should I take Xonvea and how much should I take?

Your doctor will start you on a low dose and possibly increase it – this will depend on how well the medicine works for you.

  • Take Xonvea on an empty stomach
  • Swallow the tablet whole with a glass of water
  • Do not crush, chew, or split the tablets before swallowing
  • If you cannot swallow Xonvea tablets whole, tell your doctor, pharmacist or nurse

If you take more Xonvea than advised

If you take more Xonvea than advised, stop taking Xonvea and talk to a doctor or seek medical advice as soon as possible. Take the medicine pack with you.

You may experience some of the following: feeling restless, sleepy or dizzy, dry mouth, larger black part of the eye (dilated pupils), confusion, fast heart rate.

If you want to stop taking Xonvea

Do not stop taking Xonvea without talking to your doctor first. If you stop taking this medicine suddenly your feeling sick (nausea), and being sick (vomiting), may come back. Your doctor will advise you on how to stop/ reduce your medication.

What are the likely side effects for me and how safe is doxylamine and pyridoxine for my baby?

Doxylamine and pyridoxine is a medicine combination used in pregnancy and has been prescribed to over 33 million pregnant women worldwide for 40 years. There is no evidence that doxylamine and pyridoxine is associated with an increased risk of birth defects.

However, like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may happen with this medicine:

Very common side effects (may affect more than 1 in 10 people):

  • Feeling very sleepy (if this happens do not do activities that need your full attention, for example driving, cycling or operating tools and machinery)

Common (may affect up to 1 in 10 people):

  • Feeling dizzy
  • Feeling tired
  • Dry mouth

Do not take Xonvea if you are allergic to doxylamine succinate or other antihistamines or if you are taking medicines for depression called ‘monoamine oxidase inhibitors’ (MAOIs).

Warnings and precautions

Talk to your doctor, pharmacist or nurse before taking Xonvea if you have ever had:

  • Asthma
  • Increased eye pressure
  • An eye problem called ‘narrow angle glaucoma’
  • A stomach ulcer
  • A blockage in your gut, between your stomach and small intestine
  • A blockage in your bladder

Also, talk to your doctor, pharmacist or nurse before taking Xonvea if:

  • You wish to take cough or cold treatments
  • You are taking sleeping medicines or certain pain medicines
  • You drink alcohol
  • You are taking any vitamin B supplements
  • You are taking a specific class of antidepressant called Monoamine oxidase inhibitors or MAOIs
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Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine. You can also report them to Alliance on +44 (0)1249 466966 or pharmacovigilance@alliancepharma.co.uk

Additional information

More information about Xonvea (doxylamine and pyridoxine) can be read in the patient information leaflet and summary of product characteristics: